Blocking Breast Cancer Cell Type I Ifn Signalling Prevents Immune Recognition and Allows Metastatic Progression to Bone

Dual-specific chimeric antigen receptor T cells and an indirect vaccine eradicate a variety of large solid tumors in an immunocompetent, self-antigen setting

CY Slaney, B Von Scheidt, AJ Davenport, PA Beavis, JA Westwood, S Mardiana, DC Tscharke, S Ellis, HM Prince, JA Trapani, RW Johnstone, MJ Smyth, MW Teng, A Ali, Z Yu, SA Rosenberg, NP Restifo, P Neeson, PK Darcy, MH Kershaw

2017-05-15

Purpose: While adoptive transfer of T cells bearing a chimeric antigen receptor (CAR) can eliminate substantial burdens of some le..

CD73: A potential biomarker for anti-PD-1 therapy

PA Beavis, CY Slaney, N Milenkovski, MA Henderson, S Loi, J Stagg, MH Kershaw, PK Darcy

2015-11-02

In our recent study, we show that tumoral CD73 expression limits the efficacy of anti-PD-1 therapy, and this is rescued by concomi..

Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

J Rautela, N Baschuk, CY Slaney, KM Jayatilleke, K Xiao, BN Bidwell, EC Lucas, ED Hawkins, P Lock, CS Wong, W Chen, RL Anderson, PJ Hertzog, DM Andrews, A Möller, BS Parker

2015-11-01

Metastatic progression is the major cause of breast cancer related mortality. By examining multiple syngeneic preclinical breast c..

Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic

CPM Duong, CSM Yong, MH Kershaw, CY Slaney, PK Darcy

2015-10-01

The immune system plays a critical role in the elimination and suppression of pathogens. Although the endogenous immune system is ..

Embryonic lethality in homozygous human Her-2 transgenic mice due to disruption of the Pds5b gene

CSM Yong, J Sharkey, B Duscio, B Venville, WZ Wei, RF Jones, CY Slaney, GM Arnau, AT Papenfuss, J Schröder, PK Darcy, MH Kershaw

2015-09-03

The development of antigen-targeted therapeutics is dependent on the preferential expression of tumor-associated antigens (TAA) at..

Trafficking of T cells into tumors

CY Slaney, MH Kershaw, PK Darcy

2014-12-15

T cells are a crucial component of the immune response to infection and cancer. In addition to coordinating immunity in lymphoid t..

BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity

Y Cao, CY Slaney, BN Bidwell, BS Parker, CN Johnstone, J Rautela, BL Eckhardt, RL Anderson

2014-08-29

The TGFβ growth factor family member BMP4 is a potent suppressor of breast cancer metastasis. In the mouse, the development of hig..

Clinical application of genetically modified T cells in cancer therapy

MH Kershaw, JA Westwood, CY Slaney, PK Darcy

2014-05-01

Immunotherapies are emerging as highly promising approaches for the treatment of cancer. In these approaches, a variety of materia..

The emerging role of immunosurveillance in dictating metastatic spread in breast cancer

CY Slaney, J Rautela, BS Parker

2013-10-01

It is now well known that the immune system can recognize transformed cells and control the initiation and growth of some cancers,..

The role of Type I interferons in immunoregulation of breast cancer metastasis to the bone

CY Slaney, A Möller, PJ Hertzog, BS Parker

2013-01-01

Breast cancer spread to distant sites is often incurable. Our recent findings demonstrate that Type I interferons secreted by tumo..

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

BN Bidwell, CY Slaney, NP Withana, S Forster, Y Cao, S Loi, D Andrews, T Mikeska, NE Mangan, SA Samarajiwa, NA De Weerd, J Gould, P Argani, A Müller, MJ Smyth, RL Anderson, PJ Hertzog, BS Parker

2012-08-01

Breast cancer metastasis is a key determinant of long-term patient survival. By comparing the transcriptomes of primary and metast..